TIE1

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tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol TIE1
Alt. symbols TIE, JTK14
Entrez 7075
HUGO 11809
OMIM 600222
RefSeq NM_005424
UniProt P35590
Other data
Locus Chr. 1 p34-p33

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[1]

Function[edit]

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[2] and platelets.[3] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[4]

References[edit]

  1. ^ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol. Cell. Biol. 12 (4): 1698–707. PMC 369613. PMID 1312667. 
  2. ^ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene 12 (2): 397–404. PMID 8570217. 
  3. ^ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (Nov 2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". J Vasc Res. 2000 Nov-Dec;37(6):437-42. PMID 11146396
  4. ^ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochem. Biophys. Res. Commun. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073. 

External links[edit]