TIMP1

TIMP metallopeptidase inhibitor 1
PDB rendering based on 1d2b.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1D2B, 1LQN, 1OO9, 1UEA, 2J0T, 3MA2
Identifiers
Symbols	TIMP1; CLGI; EPA; EPO; HCI; TIMP
External IDs	OMIM: 305370 MGI: 98752 HomoloGene: 36321 GeneCards: TIMP1 Gene
Gene Ontology Molecular function • enzyme inhibitor activity • protein binding • metalloendopeptidase inhibitor activity • metalloendopeptidase inhibitor activity • metal ion binding Cellular component • extracellular region • extracellular region • extracellular region • basement membrane • platelet alpha granule lumen Biological process • cell activation • platelet degranulation • aging • blood coagulation • positive regulation of cell proliferation • platelet activation • response to cytokine stimulus • wound healing • negative regulation of apoptotic process • erythrocyte maturation • response to peptide hormone stimulus • negative regulation of membrane protein ectodomain proteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7076	21857
Ensembl	ENSG00000102265	ENSMUSG00000001131
UniProt	P01033	P12032
RefSeq (mRNA)	NM_003254.2	NM_001044384.1
RefSeq (protein)	NP_003245.1	NP_001037849.1
Location (UCSC)	Chr X: 47.44 – 47.45 Mb	Chr X: 20.45 – 20.45 Mb
PubMed search	[1]	[2]

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.

This protein a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Other names

• Erythroid potentiating activity (EPA)
• Human collagenase inhibitor (HCI)

Further reading

• Hornebeck W (2004). "Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival.". Pathol. Biol. 51 (10): 569–73. doi:10.1016/j.patbio.2003.09.003. PMID 14622947. 
• Gardner J, Ghorpade A (2004). "Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system.". J. Neurosci. Res. 74 (6): 801–6. doi:10.1002/jnr.10835. PMID 14648584. 

External links

• The MEROPS online database for peptidases and their inhibitors: I35.001