This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
In melanocytic cells TIMP2 gene expression may be regulated by MITF.
^Zucker, S; Drews M, Conner C, Foda H D, DeClerck Y A, Langley K E, Bahou W F, Docherty A J, Cao J (January 1998). "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)". J. Biol. Chem. (UNITED STATES) 273 (2): 1216–22. doi:10.1074/jbc.273.2.1216. ISSN0021-9258. PMID9422789.Cite uses deprecated parameters (help)
^Overall, C M; Tam E, McQuibban G A, Morrison C, Wallon U M, Bigg H F, King A E, Roberts C R (December 2000). "Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation". J. Biol. Chem. (UNITED STATES) 275 (50): 39497–506. doi:10.1074/jbc.M005932200. ISSN0021-9258. PMID10991943.Cite uses deprecated parameters (help)
^Bigg, H F; Shi Y E, Liu Y E, Steffensen B, Overall C M (June 1997). "Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2". J. Biol. Chem. (UNITED STATES) 272 (24): 15496–500. doi:10.1074/jbc.272.24.15496. ISSN0021-9258. PMID9182583.Cite uses deprecated parameters (help)
^Kai, Heidi S-T; Butler Georgina S, Morrison Charlotte J, King Angela E, Pelman Gayle R, Overall Christopher M (December 2002). "Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain". J. Biol. Chem. (United States) 277 (50): 48696–707. doi:10.1074/jbc.M209177200. ISSN0021-9258. PMID12374789.Cite uses deprecated parameters (help)