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Tubulointerstitial nephritis antigen
Symbols TINAG ; TIN-AG
External IDs OMIM606749 MGI1349477 HomoloGene8082 GeneCards: TINAG Gene
Species Human Mouse
Entrez 27283 26944
Ensembl ENSG00000137251 ENSMUSG00000032357
UniProt Q9UJW2 n/a
RefSeq (mRNA) NM_014464 NM_012033
RefSeq (protein) NP_055279 NP_036163
Location (UCSC) Chr 6:
54.17 – 54.25 Mb
Chr 9:
76.95 – 77.05 Mb
PubMed search [1] [2]

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene.[1][2]

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM][2]


  1. ^ Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240. 
  2. ^ a b "Entrez Gene: TINAG tubulointerstitial nephritis antigen". 

Further reading[edit]

  • Katz A; Fish AJ; Santamaria P et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID 1466368. 
  • Butkowski RJ; Kleppel MM; Katz A et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi:10.1038/ki.1991.283. PMID 1762287. 
  • Fliger FD; Wieslander J; Brentjens JR et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi:10.1038/ki.1987.69. PMID 3553704. 
  • Chen Y; Krishnamurti U; Wayner EA et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi:10.1038/ki.1996.20. PMID 8770961. 
  • Nelson TR; Kim Y; Michael AF et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID 9643646. 
  • Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMID 10581025. 
  • Zhou B; Nelson TR; Kashtan C et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. PMID 10752525. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.