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TERF1 (TRF1)-interacting nuclear factor 2
Protein TINF2 PDB 3BQO.png
Rendering based on PDB 3BQO.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TINF2 ; DKCA3; TIN2
External IDs OMIM604319 MGI107246 HomoloGene8264 GeneCards: TINF2 Gene
Species Human Mouse
Entrez 26277 28113
Ensembl ENSG00000092330 ENSMUSG00000007589
UniProt Q9BSI4 Q9QXG9
RefSeq (mRNA) NM_001099274 NM_145705
RefSeq (protein) NP_001092744 NP_663751
Location (UCSC) Chr 14:
24.71 – 24.71 Mb
Chr 14:
55.68 – 55.68 Mb
PubMed search [1] [2]

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.[3]


TINF2 has been shown to interact with ACD,[4][5] POT1[4][5][6] and TERF1.[1][5][7]


  1. ^ a b Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nat Genet 23 (4): 405–12. doi:10.1038/70508. PMID 10581025. 
  2. ^ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2". 
  3. ^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". Am J Hum Genet 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230. 
  4. ^ a b Ye, Jeffrey Zheng-Sheng; Hockemeyer Dirk; Krutchinsky Andrew N; Loayza Diego; Hooper Sarah M; Chait Brian T; de Lange Titia (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes Dev. (United States) 18 (14): 1649–54. doi:10.1101/gad.1215404. ISSN 0890-9369. PMC 478187. PMID 15231715. 
  5. ^ a b c Liu, Dan; Safari Amin, O'Connor Matthew S, Chan Doug W, Laegeler Andrew, Qin Jun, Songyang Zhou (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nat. Cell Biol. (England) 6 (7): 673–80. doi:10.1038/ncb1142. ISSN 1465-7392. PMID 15181449. 
  6. ^ Loayza, Diego; De Lange Titia (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature (England) 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206. 
  7. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 

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