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TERF1 (TRF1)-interacting nuclear factor 2
Protein TINF2 PDB 3BQO.png
Rendering based on PDB 3BQO.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TINF2 ; DKCA3; TIN2
External IDs OMIM604319 MGI107246 HomoloGene8264 GeneCards: TINF2 Gene
Species Human Mouse
Entrez 26277 28113
Ensembl ENSG00000092330 ENSMUSG00000007589
UniProt Q9BSI4 Q9QXG9
RefSeq (mRNA) NM_001099274 NM_145705
RefSeq (protein) NP_001092744 NP_663751
Location (UCSC) Chr 14:
24.71 – 24.71 Mb
Chr 14:
55.68 – 55.68 Mb
PubMed search [1] [2]

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.[3]


TINF2 has been shown to interact with ACD,[4][5] POT1[4][5][6] and TERF1.[1][5][7]


  1. ^ a b Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics 23 (4): 405–12. doi:10.1038/70508. PMID 10581025. 
  2. ^ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2". 
  3. ^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230. 
  4. ^ a b Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT et al. (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715. 
  5. ^ a b c Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J et al. (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449. 
  6. ^ Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206. 
  7. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 

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