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Tolloid-like 2
Symbols TLL2 ; KIAA0932; MGC133312; MGC133313
External IDs OMIM606743 MGI1346044 HomoloGene56545 GeneCards: TLL2 Gene
RNA expression pattern
PBB GE TLL2 208027 s at tn.png
PBB GE TLL2 215008 at tn.png
PBB GE TLL2 215843 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7093 24087
Ensembl ENSG00000095587 ENSMUSG00000025013
UniProt Q9Y6L7 Q9WVM6
RefSeq (mRNA) NM_012465 NM_011904
RefSeq (protein) NP_036597 NP_036034
Location (UCSC) Chr 10:
98.12 – 98.27 Mb
Chr 19:
41.08 – 41.21 Mb
PubMed search [1] [2]

Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.[1][2]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.[2]


  1. ^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. 
  2. ^ a b "Entrez Gene: TLL2 tolloid-like 2". 

Further reading[edit]