TLN1

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Talin 1
Protein TLN1 PDB 1mix.png
PDB rendering based on 1mix.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TLN1 ; ILWEQ; TLN
External IDs OMIM186745 MGI1099832 HomoloGene21267 GeneCards: TLN1 Gene
RNA expression pattern
PBB GE TLN1 203254 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7094 21894
Ensembl ENSG00000137076 ENSMUSG00000028465
UniProt Q9Y490 P26039
RefSeq (mRNA) NM_006289 NM_011602
RefSeq (protein) NP_006280 NP_035732
Location (UCSC) Chr 9:
35.7 – 35.73 Mb
Chr 4:
43.53 – 43.56 Mb
PubMed search [1] [2]

Talin-1 is a protein that in humans is encoded by the TLN1 gene.[1][2]

This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.[3]

Interactions[edit]

TLN1 has been shown to interact with PTK2,[4][5] Paxillin[6][7][8] and CD61.[9][10]

See also[edit]

References[edit]

  1. ^ Gilmore AP, Ohanian V, Spurr NK, Critchley DR (Sep 1995). "Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p". Hum Genet 96 (2): 221–4. doi:10.1007/BF00207384. PMID 7635475. 
  2. ^ Ben-Yosef T, Francomano CA (Feb 2000). "Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern". Genomics 62 (2): 316–9. doi:10.1006/geno.1999.6019. PMID 10610730. 
  3. ^ "Entrez Gene: TLN1 talin 1". 
  4. ^ Chen, H C; Appeddu P A; Parsons J T; Hildebrand J D; Schaller M D; Guan J L (Jul 1995). "Interaction of focal adhesion kinase with cytoskeletal protein talin". J. Biol. Chem. (UNITED STATES) 270 (28): 16995–9. doi:10.1074/jbc.270.28.16995. ISSN 0021-9258. PMID 7622520. 
  5. ^ Zheng, C; Xing Z; Bian Z C; Guo C; Akbay A; Warner L; Guan J L (Jan 1998). "Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion". J. Biol. Chem. (UNITED STATES) 273 (4): 2384–9. doi:10.1074/jbc.273.4.2384. ISSN 0021-9258. PMID 9442086. 
  6. ^ Salgia, R; Sattler M; Pisick E; Li J L; Griffin J D (Feb 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. (UNITED STATES) 24 (2): 310–3. ISSN 0301-472X. PMID 8641358. 
  7. ^ Mazaki, Y; Hashimoto S; Sabe H (Mar 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins". J. Biol. Chem. (UNITED STATES) 272 (11): 7437–44. doi:10.1074/jbc.272.11.7437. ISSN 0021-9258. PMID 9054445. 
  8. ^ Salgia, R; Li J L; Lo S H; Brunkhorst B; Kansas G S; Sobhany E S; Sun Y; Pisick E; Hallek M; Ernst T (Mar 1995). "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". J. Biol. Chem. (UNITED STATES) 270 (10): 5039–47. doi:10.1074/jbc.270.10.5039. ISSN 0021-9258. PMID 7534286. 
  9. ^ Patil, S; Jedsadayanmata A, Wencel-Drake J D, Wang W, Knezevic I, Lam S C (Oct 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. (UNITED STATES) 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. ISSN 0021-9258. PMID 10497223. 
  10. ^ Calderwood, David A; Yan Boxu; de Pereda Jose M; Alvarez Begoña García; Fujioka Yosuke; Liddington Robert C; Ginsberg Mark H (Jun 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. (United States) 277 (24): 21749–58. doi:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255. 

Further reading[edit]

  • Luna EJ, Hitt AL (1992). "Cytoskeleton--plasma membrane interactions.". Science 258 (5084): 955–64. doi:10.1126/science.1439807. PMID 1439807. 
  • Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
  • Critchley DR (2005). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion". Biochem. Soc. Trans. 32 (Pt 5): 831–6. doi:10.1042/BST0320831. PMID 15494027. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.