TLR7

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Toll-like receptor 7
Identifiers
Symbols TLR7 ; TLR7-like
External IDs OMIM300365 MGI2176882 HomoloGene75060 ChEMBL: 5936 GeneCards: TLR7 Gene
RNA expression pattern
PBB GE TLR7 220146 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51284 170743
Ensembl ENSG00000196664 ENSMUSG00000044583
UniProt Q9NYK1 P58681
RefSeq (mRNA) NM_016562 NM_001290755
RefSeq (protein) NP_057646 NP_001277684
Location (UCSC) Chr X:
12.89 – 12.91 Mb
Chr X:
167.3 – 167.33 Mb
PubMed search [1] [2]

Toll-like receptor 7, also known as TLR7, is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.[1] It is a member of the toll-like receptor (TLR) family.

Function[edit]

The TLR family plays an important role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.[2]

TLR7 recognises single-stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages and dendritic cells.

Clinical significance[edit]

Imiquimod acts upon TLR7.[3]

References[edit]

  1. ^ Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119. 
  2. ^ "Entrez Gene: TLR7 toll-like receptor 7". 
  3. ^ Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (February 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nat. Immunol. 3 (2): 196–200. doi:10.1038/ni758. PMID 11812998. 

Further reading[edit]

External links[edit]