TLR8

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Toll-like receptor 8
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TLR8 ; CD288
External IDs OMIM300366 MGI2176887 HomoloGene44054 ChEMBL: 5805 GeneCards: TLR8 Gene
RNA expression pattern
PBB GE TLR8 220832 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51311 170744
Ensembl ENSG00000101916 ENSMUSG00000040522
UniProt Q9NR97 P58682
RefSeq (mRNA) NM_016610 NM_133212
RefSeq (protein) NP_057694 NP_573475
Location (UCSC) Chr X:
12.92 – 12.94 Mb
Chr X:
167.24 – 167.26 Mb
PubMed search [1] [2]

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene.[1] TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.

Function[edit]

In therms of Functionality: TLR7 is functional both in human and mouse, but TLR8 is only functional in human.[2] The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.[3]

TLR8 recognizes G-rich oligonucleotides.[4]

Clinical significance[edit]

Genetics variants in TLR8 has recently been linked to susceptibility to pulmonary tuberculosis.[5]

In therms of Functionality: TLR7 is functional both in human and mouse, but TLR8 is only functional in human.[2]

References[edit]

  1. ^ Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". European Cytokine Network 11 (3): 362–71. PMID 11022119. 
  2. ^ a b Sarvestani ST, Williams BR, Gantier MP (August 2012). "Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing". Journal of Interferon & Cytokine Research 32 (8): 350–61. doi:10.1089/jir.2012.0014. PMID 22817608. 
  3. ^ "Entrez Gene: TLR8 toll-like receptor 8". 
  4. ^ Peng G, Guo Z, Kiniwa Y, et al. (August 2005). "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function". Science 309 (5739): 1380–4. doi:10.1126/science.1113401. PMID 16123302. 
  5. ^ Davila S, Hibberd ML, Hari Dass R, et al. (October 2008). "Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis". PLoS Genetics 4 (10): e1000218. doi:10.1371/journal.pgen.1000218. PMC 2568981. PMID 18927625. 

Further reading[edit]

External links[edit]