TLR 7

Toll-like receptor 7
Identifiers
Symbols	TLR7;
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 GeneCards: TLR7 Gene
Gene Ontology Molecular function • double-stranded RNA binding • single-stranded RNA binding • transmembrane receptor activity • drug binding • siRNA binding Cellular component • cytoplasm • lysosome • endosome • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • endosome membrane • endosome membrane • integral to membrane • cytoplasmic vesicle • early phagosome Biological process • microglial cell activation involved in immune response • signal transduction • I-kappaB phosphorylation • positive regulation of chemokine production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • toll-like receptor 7 signaling pathway • response to chemical stimulus • positive regulation of NF-kappaB import into nucleus • positive regulation of interferon-gamma biosynthetic process • innate immune response • positive regulation of interferon-alpha biosynthetic process • positive regulation of interferon-beta biosynthetic process • positive regulation of interleukin-8 biosynthetic process • positive regulation of inflammatory response • defense response to virus • pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity • cellular response to mechanical stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51284	170743
Ensembl	ENSG00000196664	ENSMUSG00000044583
UniProt	Q9NYK1	Q3T997
RefSeq (mRNA)	NM_016562.3	NM_133211.3
RefSeq (protein)	NP_057646.1	NP_573474.1
Location (UCSC)	Chr X: 12.89 – 12.91 Mb	Chr X: 163.74 – 163.77 Mb
PubMed search	[1]	[2]

Toll-like receptor 7, also known as TLR7, is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.

Function

TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Clinical significance

Imiquimod acts upon TLR7.

Further reading

• Lien E, Ingalls RR (2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1–11. doi:10.1097/00003246-200201001-00001. PMID 11782555. 
• Kaisho T, Akira S (2002). "Toll-like receptors as adjuvant receptors". Biochim. Biophys. Acta 1589 (1): 1–13. doi:10.1016/S0167-4889(01)00182-3. PMID 11909637. 

External links

• MeSH Toll-Like+Receptor+7