TLX1

T-cell leukemia homeobox 1
Identifiers
Symbols	TLX1; HOX11; MGC163402; TCL3
External IDs	OMIM: 186770 MGI: 98769 HomoloGene: 4031 GeneCards: TLX1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleus Biological process • multicellular organismal development • central nervous system development • positive regulation of cell proliferation • neuron differentiation • cell fate commitment • positive regulation of transcription from RNA polymerase II promoter • spleen development • organ formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3195	21908
Ensembl	ENSG00000107807	ENSMUSG00000025215
UniProt	P31314	Q9QX99
RefSeq (mRNA)	NM_001195517.1	NM_021901.3
RefSeq (protein)	NP_001182446.1	NP_068701.1
Location (UCSC)	Chr 10: 102.89 – 102.9 Mb	Chr 19: 45.23 – 45.23 Mb
PubMed search	[1]	[2]

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene.

Interactions

TLX1 has been shown to interact with PPP1CC, PPP2CB and PPP2CA.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia.". Leuk. Lymphoma 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID 11342305. 
• Lu M, Zhang N, Ho AD (1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene 7 (7): 1325–30. PMID 1352396. 
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR, et al. (1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52618. 
• Lu M, Gong ZY, Shen WF, Ho AD (1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". EMBO J. 10 (10): 2905–10. PMC 453003. PMID 1717256. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=453003. 
• Dear TN, Colledge WH, Carlton MB, et al. (1995). "The Hox11 gene is essential for cell survival during spleen development". Development 121 (9): 2909–15. PMID 7555717. 
• Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431–5. doi:10.1073/pnas.90.10.4431. PMC 46525. PMID 8099440. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46525. 
• Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. 
• Brake RL, Kees UR, Watt PM (1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene 17 (14): 1787–95. doi:10.1038/sj.onc.1202078. PMID 9778044. 
• Zhang N, Shen W, Hawley RG, Lu M (1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene 18 (13): 2273–9. doi:10.1038/sj.onc.1202545. PMID 10327073. 
• Watt PM, Ranford PR, Kees UR (1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene 234 (1): 169–76. doi:10.1016/S0378-1119(99)00157-2. PMID 10393251. 
• Brake RL, Kees UR, Watt PM (2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochem. Biophys. Res. Commun. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735. 
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (2003). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Seq. 13 (2): 77–83. PMID 12180349. 
• Cavé H, Suciu S, Preudhomme C, et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110. 
• Hoffmann K, Dixon DN, Greene WK, et al. (2005). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes Chromosomes Cancer 41 (4): 309–20. doi:10.1002/gcc.20104. PMID 15384172. 
• Riz I, Hawley RG (2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMC 2408753. PMID 15897879. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2408753. 
• Heidari M, Rice KL, Phillips JK, et al. (2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia 20 (2): 304–12. doi:10.1038/sj.leu.2404071. PMID 16357834. 
• Chen E, Lim MS, Rosic-Kablar S, et al. (2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene 25 (18): 2575–87. doi:10.1038/sj.onc.1209285. PMID 16407851.