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T-cell leukemia homeobox 3
Symbols TLX3 ; HOX11L2; RNX
External IDs OMIM604640 MGI1351209 HomoloGene23181 GeneCards: TLX3 Gene
RNA expression pattern
PBB GE TLX3 208495 at tn.png
More reference expression data
Species Human Mouse
Entrez 30012 27140
Ensembl ENSG00000164438 ENSMUSG00000040610
UniProt O43711 O55144
RefSeq (mRNA) NM_021025 NM_019916
RefSeq (protein) NP_066305 NP_064300
Location (UCSC) Chr 5:
170.74 – 170.74 Mb
Chr 11:
33.2 – 33.2 Mb
PubMed search [1] [2]

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[1][2][3]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM][3]


  1. ^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. 
  2. ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. 
  3. ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3". 

Further reading[edit]