TLX3

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T-cell leukemia homeobox 3
Identifiers
Symbols TLX3 ; HOX11L2; RNX
External IDs OMIM604640 MGI1351209 HomoloGene23181 GeneCards: TLX3 Gene
RNA expression pattern
PBB GE TLX3 208495 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 30012 27140
Ensembl ENSG00000164438 ENSMUSG00000040610
UniProt O43711 O55144
RefSeq (mRNA) NM_021025 NM_019916
RefSeq (protein) NP_066305 NP_064300
Location (UCSC) Chr 5:
170.74 – 170.74 Mb
Chr 11:
33.2 – 33.2 Mb
PubMed search [1] [2]

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[1][2][3]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM][3]

References[edit]

  1. ^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. 
  2. ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. 
  3. ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3". 

Further reading[edit]