TM4SF5

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Transmembrane 4 L six family member 5
Identifiers
Symbol TM4SF5
External IDs OMIM604657 MGI1922854 HomoloGene2947 GeneCards: TM4SF5 Gene
RNA expression pattern
PBB GE TM4SF5 206242 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9032 75604
Ensembl ENSG00000142484 ENSMUSG00000018919
UniProt O14894 Q91XF2
RefSeq (mRNA) NM_003963 NM_029360
RefSeq (protein) NP_003954 NP_083636
Location (UCSC) Chr 17:
4.68 – 4.69 Mb
Chr 11:
70.51 – 70.51 Mb
PubMed search [1] [2]

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[2]

References[edit]

  1. ^ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038. 
  2. ^ a b "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5". 

Further reading[edit]