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Transmembrane 4 L six family member 5
Symbol TM4SF5
External IDs OMIM604657 MGI1922854 HomoloGene2947 GeneCards: TM4SF5 Gene
RNA expression pattern
PBB GE TM4SF5 206242 at tn.png
More reference expression data
Species Human Mouse
Entrez 9032 75604
Ensembl ENSG00000142484 ENSMUSG00000018919
UniProt O14894 Q91XF2
RefSeq (mRNA) NM_003963 NM_029360
RefSeq (protein) NP_003954 NP_083636
Location (UCSC) Chr 17:
4.68 – 4.69 Mb
Chr 11:
70.51 – 70.51 Mb
PubMed search [1] [2]

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[2]


  1. ^ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038. 
  2. ^ a b "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5". 

Further reading[edit]