TMOD2

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Tropomodulin 2 (neuronal)
Identifiers
Symbols TMOD2 ; N-TMOD; NTMOD
External IDs OMIM602928 MGI1355335 HomoloGene22817 GeneCards: TMOD2 Gene
Orthologs
Species Human Mouse
Entrez 29767 50876
Ensembl ENSG00000128872 ENSMUSG00000032186
UniProt Q9NZR1 Q9JKK7
RefSeq (mRNA) NM_001142885 NM_001038710
RefSeq (protein) NP_001136357 NP_001033799
Location (UCSC) Chr 15:
52.04 – 52.11 Mb
Chr 9:
75.57 – 75.61 Mb
PubMed search [1] [2]

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.[1]

Function[edit]

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

References[edit]

  1. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549. 
  2. ^ "Entrez Gene: TMOD2 , Tropomodulin 2 (neuronal)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.