TMPRSS2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Transmembrane protease, serine 2
Identifiers
Symbols TMPRSS2 ; PP9284; PRSS10
External IDs OMIM602060 MGI1354381 HomoloGene4136 ChEMBL: 1795140 GeneCards: TMPRSS2 Gene
EC number 3.4.21.-
RNA expression pattern
PBB GE TMPRSS2 205102 at tn.png
PBB GE TMPRSS2 211689 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7113 50528
Ensembl ENSG00000184012 ENSMUSG00000000385
UniProt O15393 Q9JIQ8
RefSeq (mRNA) NM_001135099 NM_015775
RefSeq (protein) NP_001128571 NP_056590
Location (UCSC) Chr 21:
42.84 – 42.9 Mb
Chr 16:
97.56 – 97.61 Mb
PubMed search [1] [2]

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.[1][2]

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. The biological function of this gene is unknown.[2]

ERG gene fusion[edit]

TMPRSS2 protein's function in prostate carcinogenesis relies on overexpression of ETS transcription factors, such as ERG and ETV1, through gene fusion. TMPRSS2-ERG fusion gene is the most frequent, present in 40% - 80% of prostate cancers in humans. ERG overexpression contributes to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling.[3]

References[edit]

  1. ^ Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE (Nov 1997). "Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3". Genomics 44 (3): 309–20. doi:10.1006/geno.1997.4845. PMID 9325052. 
  2. ^ a b "Entrez Gene: TMPRSS2 transmembrane protease, serine 2". 
  3. ^ Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM. (2010). "An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression". Cancer Cell 17 (5): 443–54. doi:10.1016/j.ccr.2010.03.018. PMC 2874722. PMID 20478527. 

Further reading[edit]