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Thymosin beta 10
Symbols TMSB10 ; MIG12; TB10
External IDs OMIM188399 GeneCards: TMSB10 Gene
RNA expression pattern
PBB GE TMSB10 217733 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9168 n/a
Ensembl ENSG00000034510 n/a
UniProt P63313 n/a
RefSeq (mRNA) NM_021103 n/a
RefSeq (protein) NP_066926 n/a
Location (UCSC) Chr 2:
85.13 – 85.13 Mb
PubMed search [1] n/a

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene.[1][2][3] TMSB10 is a member of the beta-thymosin are a family of peptides.

TMSB10 plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).[citation needed]


  1. ^ McCreary V, Kartha S, Bell GI, Toback FG (Jun 1988). "Sequence of a human kidney cDNA clone encoding thymosin beta 10". Biochem Biophys Res Commun 152 (2): 862–6. doi:10.1016/S0006-291X(88)80118-9. PMID 3365256. 
  2. ^ Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A (Oct 1999). "Thymosin beta-10 gene overexpression is a general event in human carcinogenesis". Am J Pathol 155 (3): 799–804. doi:10.1016/s0002-9440(10)65178-4. PMC 1866886. PMID 10487837. 
  3. ^ "Entrez Gene: TMSB10 thymosin, beta 10". 

Further reading[edit]

  • Tsitsiloni OE, Yialouris PP, Echner H et al. (1992). "Evidence for the extranuclear localization of thymosins in thymus.". Experientia 48 (4): 398–402. doi:10.1007/BF01923441. PMID 1582498. 
  • Condon MR, Hall AK (1992). "Expression of thymosin beta-4 and related genes in developing human brain.". J. Mol. Neurosci. 3 (3): 165–70. doi:10.1007/BF02919408. PMID 1627460. 
  • Lin SC, Morrison-Bogorad M (1992). "Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells.". J. Biol. Chem. 266 (34): 23347–53. PMID 1744129. 
  • Hall AK (1991). "Differential expression of thymosin genes in human tumors and in the developing human kidney.". Int. J. Cancer 48 (5): 672–7. doi:10.1002/ijc.2910480507. PMID 2071228. 
  • Hall AK, Hempstead J, Morgan JI (1990). "Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma.". Brain Res. Mol. Brain Res. 8 (2): 129–35. doi:10.1016/0169-328X(90)90057-K. PMID 2169566. 
  • Weterman MA, van Muijen GN, Ruiter DJ, Bloemers HP (1993). "Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma.". Int. J. Cancer 53 (2): 278–84. doi:10.1002/ijc.2910530218. PMID 8425765. 
  • Lapteva N, Ando Y, Nieda M et al. (2001). "Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array.". Br. J. Haematol. 114 (1): 191–7. doi:10.1046/j.1365-2141.2001.02910.x. PMID 11472367. 
  • Bani-Yaghoub M, Felker JM, Ozog MA et al. (2002). "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells.". Biochem. Cell Biol. 79 (4): 387–98. doi:10.1139/bcb-79-4-387. PMID 11527208. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Santelli G, Bartoli PC, Giuliano A et al. (2003). "Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.". Thyroid 12 (9): 765–72. doi:10.1089/105072502760339325. PMID 12481941. 
  • Johansson U, Olsson A, Gabrielsson S et al. (2003). "Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation.". Biochem. Biophys. Res. Commun. 308 (3): 474–9. doi:10.1016/S0006-291X(03)01392-5. PMID 12914774. 
  • Rho SB, Chun T, Lee SH et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture.". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341. 
  • Chiappetta G, Pentimalli F, Monaco M et al. (2005). "Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncol. Rep. 12 (2): 239–43. doi:10.3892/or.12.2.239. PMID 15254683. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Lee SH, Son MJ, Oh SH et al. (2005). "Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function.". Cancer Res. 65 (1): 137–48. PMID 15665289. 
  • Rho SB, Lee KW, Chun T et al. (2005). "The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling". J. Biol. Chem. 280 (40): 34003–7. doi:10.1074/jbc.M501629200. PMID 16012174. 
  • Maelan AE, Rasmussen TK, Larsson LI (2007). "Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility". Histochem. Cell Biol. 127 (1): 109–13. doi:10.1007/s00418-006-0208-z. PMID 16786322. 
  • Kim SC, Sprung R, Chen Y et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.