TNFRSF10A

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Tumor necrosis factor receptor superfamily, member 10a
Identifiers
Symbols TNFRSF10A ; APO2; CD261; DR4; TRAILR-1; TRAILR1
External IDs OMIM603611 MGI1341090 HomoloGene129806 ChEMBL: 3551 GeneCards: TNFRSF10A Gene
Orthologs
Species Human Mouse
Entrez 8797 21933
Ensembl ENSG00000104689 ENSMUSG00000022074
UniProt O00220 Q9QZM4
RefSeq (mRNA) NM_003844 NM_020275
RefSeq (protein) NP_003835 NP_064671
Location (UCSC) Chr 8:
23.05 – 23.08 Mb
Chr 14:
69.77 – 69.78 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 10A is a protein that in humans is encoded by the TNFRSF10A gene.[1][2] also known as DR4 or TRAIL-R1

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[3]

Interactions[edit]

TNFRSF10A has been shown to interact with DAP3.[4]

References[edit]

  1. ^ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998. 
  2. ^ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980. 
  3. ^ "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a". 
  4. ^ Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. (United States) 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. 

Further reading[edit]