Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.
TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.
In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.
^ abWu, Y; Bressette D, Carrell J A, Kaufman T, Feng P, Taylor K, Gan Y, Cho Y H, Garcia A D, Gollatz E, Dimke D, LaFleur D, Migone T S, Nardelli B, Wei P, Ruben S M, Ullrich S J, Olsen H S, Kanakaraj P, Moore P A, Baker K P (November 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. (UNITED STATES) 275 (45): 35478–85. doi:10.1074/jbc.M005224200. ISSN0021-9258. PMID10956646.Cite uses deprecated parameters (help)
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