B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
Yan M, Brady JR, Chan B, et al. (2002). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.". Curr. Biol.11 (19): 1547–52. doi:10.1016/S0960-9822(01)00481-X. PMID11591325.
Xu LG, Shu HB (2003). "TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production.". J. Immunol.169 (12): 6883–9. PMID12471121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
Kim HM, Yu KS, Lee ME, et al. (2003). "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation.". Nat. Struct. Biol.10 (5): 342–8. doi:10.1038/nsb925. PMID12715002.
Liu Y, Hong X, Kappler J, et al. (2003). "Ligand-receptor binding revealed by the TNF family member TALL-1.". Nature423 (6935): 49–56. doi:10.1038/nature01543. PMID12721620.
Gordon NC, Pan B, Hymowitz SG, et al. (2003). "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.". Biochemistry42 (20): 5977–83. doi:10.1021/bi034017g. PMID12755599.