Tumor necrosis factor receptor superfamily member 14 is a protein that in humans is encoded by the TNFRSF14gene. It is also known as "herpesvirus entry mediator" (HVEM).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.
In melanocytic cells TNFRSF14 gene expression may be regulated by MITF.
^Montgomery RI, Warner MS, Lum BJ, Spear PG (Dec 1996). "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family". Cell87 (3): 427–36. doi:10.1016/S0092-8674(00)81363-X. PMID8898196.
^Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK, Kim YJ, Wang S, Gentz R, Yu GL, Harrop J, Lyn SD, Silverman C, Porter TG, Truneh A, Young PR (June 1997). "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation". J Biol Chem272 (22): 14272–6. doi:10.1074/jbc.272.22.14272. PMID9162061.
^Ware, Carl (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul, William. Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN0-7817-6519-6.
^ abHsu, H; Solovyev I; Colombero A; Elliott R; Kelley M; Boyle W J (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN0021-9258. PMID9153189.
^ abMarsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN0021-9258. PMID9162022.
Hsu H, Solovyev I, Colombero A, et al. (1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem.272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. PMID9153189.
Marsters SA, Ayres TM, Skubatch M, et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem.272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID9162022.
Mauri DN, Ebner R, Montgomery RI, et al. (1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity8 (1): 21–30. doi:10.1016/S1074-7613(00)80455-0. PMID9462508.
Franco PJ, Farooqui M, Seto E, Wei LN (2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol.15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID11463856.
Bobik A, Kalinina N (2002). "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis". Arterioscler. Thromb. Vasc. Biol.21 (12): 1873–5. PMID11742858.
Struyf F, Posavad CM, Keyaerts E, et al. (2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". J. Infect. Dis.185 (1): 36–44. doi:10.1086/338116. PMID11756979.
Carfí A, Gong H, Lou H, et al. (2002). "Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA". Acta Crystallogr. D Biol. Crystallogr.58 (Pt 5): 836–8. doi:10.1107/S0907444902001270. PMID11976496.
Hu YC, Shyr CR, Che W, et al. (2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". J. Biol. Chem.277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID12093804.
Jung HW, La SJ, Kim JY, et al. (2004). "High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases". Exp. Mol. Med.35 (6): 501–8. doi:10.1038/emm.2003.65. PMID14749527.
Krummenacher C, Baribaud F, Ponce de Leon M, et al. (2004). "Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus". Virology322 (2): 286–99. doi:10.1016/j.virol.2004.02.005. PMID15110526.