Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
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Kojima T, Morikawa Y, Copeland NG, et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles". J. Biol. Chem.275 (27): 20742–7. doi:10.1074/jbc.M002691200. PMID10764796.
Eby MT, Jasmin A, Kumar A, et al. (2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death". J. Biol. Chem.275 (20): 15336–42. doi:10.1074/jbc.275.20.15336. PMID10809768.
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Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res.13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res.14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID15489334.
Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors". Neuron45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID15694321.
Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID15694322.
Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target". Int. J. Cancer120 (6): 1304–10. doi:10.1002/ijc.22367. PMID17187358.
Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol.33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID17239012.