Tumor necrosis factor receptor superfamily member 6B also known as DcR3(Decoy Receptor 3) and M68 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database. It is a protein that in humans is encoded by the TNFRSF6Bgene. The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.
^ abPitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature396 (6712): 699–703. doi:10.1038/25387. PMID9872321.
^ abcYu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID10318773.
Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res.6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID10470851.
Hsu TL, Chang YC, Chen SJ et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol.168 (10): 4846–53. PMID11994433.
Mild G, Bachmann F, Boulay JL et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer". Int. J. Cancer102 (3): 254–7. doi:10.1002/ijc.10711. PMID12397645.
Tsuji S, Hosotani R, Yonehara S et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma". Int. J. Cancer106 (1): 17–25. doi:10.1002/ijc.11170. PMID12794752.
Shi G, Wu Y, Zhang J, Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo". J. Immunol.171 (7): 3407–14. PMID14500635.
Wu SF, Liu TM, Lin YC et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication". J. Leukoc. Biol.75 (2): 293–306. doi:10.1189/jlb.0303119. PMID14634066.
Chang YC, Hsu TL, Lin HH et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3". J. Leukoc. Biol.75 (3): 486–94. doi:10.1189/jlb.0903448. PMID14657214.