TNFRSF6B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tumor necrosis factor receptor superfamily, member 6b, decoy
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TNFRSF6B ; DCR3; DJ583P15.1.1; M68; M68E; TR6
External IDs OMIM603361 HomoloGene48242 GeneCards: TNFRSF6B Gene
Orthologs
Species Human Mouse
Entrez 8771 n/a
Ensembl ENSG00000243509 n/a
UniProt O95407 n/a
RefSeq (mRNA) NM_003823 n/a
RefSeq (protein) NP_003814 n/a
Location (UCSC) Chr 20:
62.33 – 62.33 Mb
n/a
PubMed search [1] n/a

Tumor necrosis factor receptor superfamily member 6B also known as DcR3(Decoy Receptor 3) and M68 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database. It is a protein that in humans is encoded by the TNFRSF6B gene.[1][2][3] The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[3] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

Function[edit]

This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.[3]

Interactions[edit]

TNFRSF6B has been shown to interact with:

References[edit]

  1. ^ a b Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. 
  2. ^ a b c Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773. 
  3. ^ a b c "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy". 
  4. ^ Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J (June 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. 107 (11): 1459–68. doi:10.1172/JCI12159. PMC 209323. PMID 11390428. 
  5. ^ a b Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL (May 2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. PMID 11994433. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.