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Tumor necrosis factor (ligand) superfamily, member 13
Symbols TNFSF13 ; APRIL; CD256; TALL-2; TALL2; TRDL-1; ZTNF2
External IDs OMIM604472 MGI1916833 HomoloGene56971 GeneCards: TNFSF13 Gene
Species Human Mouse
Entrez 8741 69583
Ensembl ENSG00000161955 ENSMUSG00000089669
UniProt O75888 Q9D777
RefSeq (mRNA) NM_001198622 NM_001159505
RefSeq (protein) NP_001185551 NP_001152977
Location (UCSC) Chr 17:
7.46 – 7.46 Mb
Chr 11:
69.68 – 69.69 Mb
PubMed search [1] [2]

Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation-inducing ligand (APRIL) is a protein that in humans is encoded by the TNFSF13 gene.[1][2] TNFSF13 has also been designated CD256 (cluster of differentiation 256).


The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[2]


TNFSF13 has been shown to interact with TNFRSF13B[3] and B-cell activating factor.[4]


  1. ^ Hahne M, Kataoka T, Schroter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE, Sordat B, Rimoldi D, Tschopp J (Oct 1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J Exp Med 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536. 
  2. ^ a b "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13". 
  3. ^ Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (November 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646. 
  4. ^ Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS (October 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.