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Tumor necrosis factor (ligand) superfamily, member 18
Protein TNFSF18 PDB 2Q1M.png
Rendering based on PDB 2Q1M.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603898 MGI2673064 HomoloGene3732 GeneCards: TNFSF18 Gene
RNA expression pattern
PBB GE TNFSF18 221371 at tn.png
More reference expression data
Species Human Mouse
Entrez 8995 240873
Ensembl ENSG00000120337 ENSMUSG00000066755
UniProt Q9UNG2 Q7TS55
RefSeq (mRNA) NM_005092 NM_183391
RefSeq (protein) NP_005083 NP_899247
Location (UCSC) Chr 1:
173.04 – 173.05 Mb
Chr 1:
161.49 – 161.51 Mb
PubMed search [1] [2]

Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.[1][2][3]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.[3]


  1. ^ Kwon B, Yu KY, Ni J, Yu GL, Jang IK, Kim YJ, Xing L, Liu D, Wang SX, Kwon BS (Mar 1999). "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand". J Biol Chem 274 (10): 6056–61. doi:10.1074/jbc.274.10.6056. PMID 10037686. 
  2. ^ Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A (Apr 1999). "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR". Curr Biol 9 (4): 215–8. doi:10.1016/S0960-9822(99)80093-1. PMID 10074428. 
  3. ^ a b "Entrez Gene: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18". 

Further reading[edit]