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Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Protein TNKS PDB 2rf5.png
Rendering based on PDB 2rf5.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603303 MGI1341087 HomoloGene18405 ChEMBL: 6164 GeneCards: TNKS Gene
EC number
RNA expression pattern
PBB GE TNKS 202561 at tn.png
PBB GE TNKS 216695 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8658 21951
Ensembl ENSG00000173273 ENSMUSG00000031529
UniProt O95271 Q6PFX9
RefSeq (mRNA) NM_003747 NM_175091
RefSeq (protein) NP_003738 NP_780300
Location (UCSC) Chr 8:
9.41 – 9.64 Mb
Chr 8:
34.83 – 34.97 Mb
PubMed search [1] [2]

Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.[1][2][3]


TNKS has been shown to interact with MCL1,[4] TNKS1BP1,[5][6] FNBP1[7] and TERF1.[1][5][6][8][9]


  1. ^ a b Smith S, Giriat I, Schmitt A, de Lange T (Dec 1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science 282 (5393): 1484–7. doi:10.1126/science.282.5393.1484. PMID 9822378. 
  2. ^ Zhu L, Smith S, de Lange T, Seldin MF (May 1999). "Chromosomal mapping of the tankyrase gene in human and mouse". Genomics 57 (2): 320–1. doi:10.1006/geno.1999.5771. PMID 10198177. 
  3. ^ "Entrez Gene: TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase". 
  4. ^ Bae, Jeehyeon; Donigian Jill R; Hsueh Aaron J W (Feb 2003). "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis". J. Biol. Chem. (United States) 278 (7): 5195–204. doi:10.1074/jbc.M201988200. ISSN 0021-9258. PMID 12475993. 
  5. ^ a b Seimiya, Hiroyuki; Smith Susan (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. (United States) 277 (16): 14116–26. doi:10.1074/jbc.M112266200. ISSN 0021-9258. PMID 11854288. 
  6. ^ a b Sbodio, Juan I; Chi Nai-Wen (Aug 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. (United States) 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061. 
  7. ^ Fuchs, U; Rehkamp G F; Slany R; Follo M; Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. (Netherlands) 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. ISSN 0014-5793. PMID 14596906. 
  8. ^ Cook, Brandoch D; Dynek Jasmin N; Chang William; Shostak Grigoriy; Smith Susan (Jan 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. (United States) 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745. 
  9. ^ Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (Feb 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. (England) 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774. 

Further reading[edit]