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Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Protein TNKS2 PDB 3KR7.png
Rendering based on PDB 3KR7.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607128 MGI1921743 HomoloGene11890 ChEMBL: 6154 GeneCards: TNKS2 Gene
EC number
Species Human Mouse
Entrez 80351 74493
Ensembl ENSG00000107854 ENSMUSG00000024811
UniProt Q9H2K2 Q3UES3
RefSeq (mRNA) NM_025235 NM_001163635
RefSeq (protein) NP_079511 NP_001157107
Location (UCSC) Chr 10:
91.8 – 91.87 Mb
Chr 19:
36.83 – 36.89 Mb
PubMed search [1] [2]

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.[1]


TNKS2 has been shown to interact with GRB14,[2] TERF1[3][4][5] and Cystinyl aminopeptidase.[4][5][6]


  1. ^ "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2". 
  2. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563. 
  3. ^ Cook, Brandoch D; Dynek Jasmin N; Chang William; Shostak Grigoriy; Smith Susan (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. (United States) 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745. 
  4. ^ a b Chi, N W; Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. (UNITED STATES) 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299. 
  5. ^ a b Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. (England) 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774. 
  6. ^ Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. (United States) 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061. 

Further reading[edit]