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Trinucleotide repeat containing 6B
Symbols TNRC6B ; KIAA1093
External IDs OMIM610740 MGI2443730 HomoloGene66194 GeneCards: TNRC6B Gene
RNA expression pattern
PBB GE TNRC6B 213254 at tn.png
More reference expression data
Species Human Mouse
Entrez 23112 213988
Ensembl ENSG00000100354 ENSMUSG00000047888
UniProt Q9UPQ9 Q8BKI2
RefSeq (mRNA) NM_001024843 NM_144812
RefSeq (protein) NP_001020014 NP_659061
Location (UCSC) Chr 22:
40.44 – 40.73 Mb
Chr 15:
80.71 – 80.94 Mb
PubMed search [1] [2]

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[1]


TNRC6B has been shown to interact with EIF2C2.[2] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[3]


  1. ^ "Entrez Gene: TNRC6B trinucleotide repeat containing 6B". 
  2. ^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. 
  3. ^ Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. PMID 16289642. 

Further reading[edit]