TNRC6B

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Trinucleotide repeat containing 6B
Identifiers
Symbols TNRC6B ; KIAA1093
External IDs OMIM610740 MGI2443730 HomoloGene66194 GeneCards: TNRC6B Gene
RNA expression pattern
PBB GE TNRC6B 213254 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23112 213988
Ensembl ENSG00000100354 ENSMUSG00000047888
UniProt Q9UPQ9 Q8BKI2
RefSeq (mRNA) NM_001024843 NM_144812
RefSeq (protein) NP_001020014 NP_659061
Location (UCSC) Chr 22:
40.44 – 40.73 Mb
Chr 15:
80.71 – 80.94 Mb
PubMed search [1] [2]

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[1]

Interactions[edit]

TNRC6B has been shown to interact with EIF2C2.[2] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[3]

References[edit]

  1. ^ "Entrez Gene: TNRC6B trinucleotide repeat containing 6B". 
  2. ^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. 
  3. ^ Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. PMID 16289642. 

Further reading[edit]