TNS1

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Tensin 1
Identifiers
Symbols TNS1 ; MST091; MST122; MST127; MSTP122; MSTP127; MXRA6; PPP1R155; TNS
External IDs OMIM600076 MGI104552 HomoloGene11219 GeneCards: TNS1 Gene
RNA expression pattern
PBB GE TNS1 221246 x at tn.png
PBB GE TNS1 218863 s at tn.png
PBB GE TNS1 218864 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7145 21961
Ensembl ENSG00000079308 ENSMUSG00000055322
UniProt Q9HBL0 E9Q0S6
RefSeq (mRNA) NM_022648 NM_001289895
RefSeq (protein) NP_072174 NP_001276824
Location (UCSC) Chr 2:
218.66 – 218.87 Mb
Chr 1:
73.91 – 74.12 Mb
PubMed search [1] [2]

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[1]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[1]

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