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Target of myb1 (chicken)
Protein TOM1 PDB 1elk.png
PDB rendering based on 1elk.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TOM1 ; FLJ33404
External IDs OMIM604700 HomoloGene88453 GeneCards: TOM1 Gene
RNA expression pattern
PBB GE TOM1 202807 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10043 21968
Ensembl ENSG00000100284 ENSMUSG00000037827
UniProt O60784 O88746
RefSeq (mRNA) NM_001135729 NM_001136259
RefSeq (protein) NP_001129201 NP_001129731
Location (UCSC) Chr 22:
35.7 – 35.74 Mb
Chr 6:
128.64 – 128.65 Mb
PubMed search [1] [2]

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.[1][2][3]

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.[3]


TOM1 has been shown to interact with TOLLIP[4] and ZFYVE16.[5]


  1. ^ Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004. 
  2. ^ Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (May 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J Biol Chem 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686. 
  3. ^ a b "Entrez Gene: TOM1 target of myb1 (chicken)". 
  4. ^ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. (United States) 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850. 
  5. ^ Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. (United States) 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930. 

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