DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2Agene.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
^Tsai, S C; Valkov N, Yang W M, Gump J, Sullivan D, Seto E (November 2000). "Histone deacetylase interacts directly with DNA topoisomerase II". Nat. Genet. (UNITED STATES) 26 (3): 349–53. doi:10.1038/81671. ISSN1061-4036. PMID11062478.Cite uses deprecated parameters (help)
^Johnson, C A; Padget K, Austin C A, Turner B M (February 2001). "Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis". J. Biol. Chem. (United States) 276 (7): 4539–42. doi:10.1074/jbc.C000824200. ISSN0021-9258. PMID11136718.Cite uses deprecated parameters (help)
^Cowell, I G; Okorokov A L, Cutts S A, Padget K, Bell M, Milner J, Austin C A (February 2000). "Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53". Exp. Cell Res. (UNITED STATES) 255 (1): 86–94. doi:10.1006/excr.1999.4772. ISSN0014-4827. PMID10666337.Cite uses deprecated parameters (help)