TP53RK

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TP53 regulating kinase
Identifiers
Symbols TP53RK ; BUD32; C20orf64; Nori-2; Nori-2p; PRPK; dJ101A2
External IDs OMIM608679 MGI1914050 HomoloGene6042 GeneCards: TP53RK Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 112858 76367
Ensembl ENSG00000172315 ENSMUSG00000042854
UniProt Q96S44 Q99PW4
RefSeq (mRNA) NM_033550 NM_023815
RefSeq (protein) NP_291028 NP_076304
Location (UCSC) Chr 20:
45.31 – 45.32 Mb
Chr 2:
166.79 – 166.8 Mb
PubMed search [1] [2]

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.[1][2][3] This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control,[4] telomere regulation [5] and tRNA modification.[6]


References[edit]

  1. ^ Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". J Biol Chem 276 (47): 44003–11. doi:10.1074/jbc.M105669200. PMID 11546806. 
  2. ^ Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Gotz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Lett 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID 12914926. 
  3. ^ "Entrez Gene: TP53RK TP53 regulating kinase". 
  4. ^ Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D. (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". EMBO J. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMID 16874308. 
  5. ^ Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. 
  6. ^ Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R. (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.". Embo J. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMID 21183954. 

Further reading[edit]