TPD52

Tumor protein D52
Identifiers
Symbols	TPD52; D52; N8L; PC-1; PrLZ; hD52
External IDs	OMIM: 604068 MGI: 107749 HomoloGene: 38007 GeneCards: TPD52 Gene
Gene Ontology Molecular function • calcium ion binding • protein binding • identical protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • cytoplasm • endoplasmic reticulum • perinuclear region of cytoplasm Biological process • anatomical structure morphogenesis • B cell differentiation • secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7163	21985
Ensembl	ENSG00000076554	ENSMUSG00000027506
UniProt	P55327	Q545M5
RefSeq (mRNA)	NM_001025252.1	NM_001025261
RefSeq (protein)	NP_001020423.1	NP_001020432
Location (UCSC)	Chr 8: 80.87 – 81.14 Mb	Chr 3: 8.91 – 8.95 Mb
PubMed search	[1]	[2]

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.

Interactions

TPD52 has been shown to interact with TPD52L2, TPD52L1 and MAL2.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Chen SL, Maroulakou IG, Green JE, et al. (1996). "Isolation and characterization of a novel gene expressed in multiple cancers.". Oncogene 12 (4): 741–51. PMID 8632896. 
• Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52).". Genomics 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.". Oncogene 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. 
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595. 
• Wilson SH, Bailey AM, Nourse CR, et al. (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system.". Genomics 76 (1-3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320. 
• Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52.". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Wang R, Xu J, Saramäki O, et al. (2004). "PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer.". Cancer Res. 64 (5): 1589–94. doi:10.1158/0008-5472.CAN-03-3331. PMID 14996714. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Tiacci E, Orvietani PL, Bigerna B, et al. (2005). "Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI.". Blood 105 (7): 2812–20. doi:10.1182/blood-2004-07-2630. PMID 15576473. 
• Byrne JA, Balleine RL, Schoenberg Fejzo M, et al. (2005). "Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer.". Int. J. Cancer 117 (6): 1049–54. doi:10.1002/ijc.21250. PMID 15986428. 
• Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967. 
• Cao Q, Chen J, Zhu L, et al. (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.