TPD52L1

Tumor protein D52-like 1
Identifiers
Symbols	TPD52L1; D53; MGC8556; TPD52L2; hD53
External IDs	OMIM: 604069 MGI: 1298386 HomoloGene: 2468 GeneCards: TPD52L1 Gene
Gene Ontology Molecular function • protein binding • caspase activator activity • identical protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • cytoplasm • perinuclear region of cytoplasm Biological process • G2/M transition of mitotic cell cycle • DNA fragmentation involved in apoptotic nuclear change • induction of apoptosis • activation of caspase activity • positive regulation of MAP kinase activity • positive regulation of JNK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7164	21987
Ensembl	ENSG00000111907	ENSMUSG00000000296
UniProt	Q16890	Q3V2G6
RefSeq (mRNA)	NM_001003395.1	NM_009413.1
RefSeq (protein)	NP_001003395.1	NP_033439.1
Location (UCSC)	Chr 6: 125.44 – 125.59 Mb	Chr 10: 31.05 – 31.17 Mb
PubMed search	[1]	[2]

Tumor protein D53 is a protein that in humans is encoded by the TPD52L1 gene.

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.

Interactions

TPD52L1 has been shown to interact with TPD52L2 and TPD52.

Further reading

• Byrne JA, Tomasetto C, Garnier JM, et al. (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence.". Cancer Res. 55 (13): 2896–903. PMID 7796418. 
• Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.". Oncogene 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. 
• Byrne JA, Mattei MG, Basset P, Gunning P (1998). "Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2.". Cytogenet. Cell Genet. 81 (3-4): 199–201. doi:10.1159/000015029. PMID 9730602. 
• Wilson SH, Bailey AM, Nourse CR, et al. (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system.". Genomics 76 (1-3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320. 
• Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52.". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Cho S, Ko HM, Kim JM, et al. (2004). "Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.". J. Biol. Chem. 279 (16): 16050–6. doi:10.1074/jbc.M305758200. PMID 14761963. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967. 
• Cao Q, Chen J, Zhu L, et al. (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.