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Thiamin pyrophosphokinase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TPK1 ; HTPK1; PP20; THMD5
External IDs OMIM606370 MGI1352500 HomoloGene6960 ChEMBL: 6155 GeneCards: TPK1 Gene
EC number
RNA expression pattern
PBB GE TPK1 221218 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27010 29807
Ensembl ENSG00000196511 ENSMUSG00000029735
UniProt Q9H3S4 Q9R0M5
RefSeq (mRNA) NM_001042482 NM_013861
RefSeq (protein) NP_001035947 NP_038889
Location (UCSC) Chr 7:
144.45 – 144.84 Mb
Chr 6:
43.35 – 43.67 Mb
PubMed search [1] [2]

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.[1][2]

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


  1. ^ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111. 
  2. ^ a b "Entrez Gene: TPK1 thiamin pyrophosphokinase 1". 

Further reading[edit]