TPSB2

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Tryptase beta 2 (gene/pseudogene)
PDB 2fs9 EBI.jpg
PDB rendering based on 2fs9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TPSB2 ; TPS2; tryptaseB; tryptaseC
External IDs OMIM191081 MGI96942 HomoloGene55729 GeneCards: TPSB2 Gene
EC number 3.4.21.59
Orthologs
Species Human Mouse
Entrez 64499 17229
Ensembl ENSG00000197253 ENSMUSG00000033825
UniProt P20231 P21845
RefSeq (mRNA) NM_024164 NM_010781
RefSeq (protein) NP_077078 NP_034911
Location (UCSC) Chr 16:
1.28 – 1.28 Mb
Chr 17:
25.37 – 25.37 Mb
PubMed search [1] [2]

Tryptase beta-2, also known as tryptase II, is an enzyme that in humans is encoded by the TPSB2 gene.[1]

Function[edit]

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.[1]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.