TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositolphospholipids. TPTE is believed to lack phosphatase activity; however, the closely related protein TPIP, also called TPTE2 is an active phosphatase with activity against inositol phospholipid substrates. TPTE and TPIP are the mammalian homologues to the family of voltage sensitive phosphatases.
Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet.105 (5): 399–409. doi:10.1007/s004390051122. PMID10598804.
Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21.". Hum. Genet.107 (2): 127–31. doi:10.1007/s004390000343. PMID11030409.
Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.". J. Biol. Chem.276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID11279206.
Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family.". Hum. Genet.109 (6): 569–75. doi:10.1007/s004390100607. PMID11810268.