TRADD

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TNFRSF1A-associated via death domain
Protein TRADD PDB 1f2h.png
PDB rendering based on 1f2h.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TRADD ; Hs.89862
External IDs OMIM603500 MGI109200 HomoloGene2807 GeneCards: TRADD Gene
RNA expression pattern
PBB GE TRADD 1729 at tn.png
PBB GE TRADD 205641 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8717 71609
Ensembl ENSG00000102871 ENSMUSG00000031887
UniProt Q15628 Q3U0V2
RefSeq (mRNA) NM_003789 NM_001033161
RefSeq (protein) NP_003780 NP_001028333
Location (UCSC) Chr 16:
67.19 – 67.19 Mb
Chr 8:
105.26 – 105.26 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.[1][2]

TRADD is an adaptor protein.

Function[edit]

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.[2]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions[edit]

TRADD has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Hsu H, Xiong J, Goeddel DV (June 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell 81 (4): 495–504. doi:10.1016/0092-8674(95)90070-5. PMID 7758105. 
  2. ^ a b "Entrez Gene: TRADD TNFRSF1A-associated via death domain". 
  3. ^ a b c Hsu H, Shu HB, Pan MG, Goeddel DV (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell 84 (2): 299–308. doi:10.1016/s0092-8674(00)80984-8. PMID 8565075. 
  4. ^ Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP (September 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". J. Neurochem. 86 (5): 1260–70. doi:10.1046/j.1471-4159.2003.01934.x. PMID 12911633. 
  5. ^ Thomas LR, Stillman DJ, Thorburn A (September 2002). "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen". J. Biol. Chem. 277 (37): 34343–8. doi:10.1074/jbc.M204169200. PMID 12107169. 
  6. ^ Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T et al. (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155 (3): 415–26. doi:10.1083/jcb.200103078. PMC 2150850. PMID 11684708. 
  7. ^ a b Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity 4 (4): 387–96. doi:10.1016/s1074-7613(00)80252-6. PMID 8612133. 
  8. ^ Wang Y, Wu TR, Cai S, Welte T, Chin YE (July 2000). "Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation". Mol. Cell. Biol. 20 (13): 4505–12. doi:10.1128/mcb.20.13.4505-4512.2000. PMC 85828. PMID 10848577. 
  9. ^ Jiang Y, Woronicz JD, Liu W, Goeddel DV (January 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science 283 (5401): 543–6. doi:10.1126/science.283.5401.543. PMID 9915703. 
  10. ^ Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse ML et al. (April 1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805. 
  11. ^ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J et al. (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980. 
  12. ^ Shu HB, Takeuchi M, Goeddel DV (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. PMC 19479. PMID 8943045. 
  13. ^ Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A et al. (January 2009). "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)". Biochem. J. 417 (1): 149–60. doi:10.1042/BJ20081885. PMID 18939944. 
  14. ^ Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT et al. (November 1996). "A death-domain-containing receptor that mediates apoptosis". Nature 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525. 
  15. ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  16. ^ Takeuchi M, Rothe M, Goeddel DV (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708. 
  17. ^ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC et al. (June 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell 101 (7): 777–87. doi:10.1016/s0092-8674(00)80889-2. PMID 10892748. 
  18. ^ Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY et al. (June 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell 5 (6): 1051–7. doi:10.1016/s1097-2765(00)80270-1. PMID 10911999. 
  19. ^ Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S et al. (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. 276 (39): 36530–4. doi:10.1074/jbc.M104837200. PMID 11479302. 
  20. ^ Malinin NL, Boldin MP, Kovalenko AV, Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature 385 (6616): 540–4. doi:10.1038/385540a0. PMID 9020361. 


Further reading[edit]

External links[edit]