TRADD

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TNFRSF1A-associated via death domain
Protein TRADD PDB 1f2h.png
PDB rendering based on 1f2h.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TRADD ; Hs.89862
External IDs OMIM603500 MGI109200 HomoloGene2807 GeneCards: TRADD Gene
RNA expression pattern
PBB GE TRADD 1729 at tn.png
PBB GE TRADD 205641 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8717 71609
Ensembl ENSG00000102871 ENSMUSG00000031887
UniProt Q15628 Q3U0V2
RefSeq (mRNA) NM_003789 NM_001033161
RefSeq (protein) NP_003780 NP_001028333
Location (UCSC) Chr 16:
67.19 – 67.19 Mb
Chr 8:
105.26 – 105.26 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.[1][2]

TRADD is an adaptor protein.

Function[edit]

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.[2]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions[edit]

TRADD has been shown to interact with STAT1,[3] TNFRSF1A,[4][5][6][7][8][9][10] FADD,[8][11][12] TNFRSF25,[13] TRAF2,[8][14][15][16][17][18][19] Keratin 18[20] and RIPK1.[7]

See also[edit]

References[edit]

  1. ^ Hsu H, Xiong J, Goeddel DV (June 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell 81 (4): 495–504. doi:10.1016/0092-8674(95)90070-5. PMID 7758105. 
  2. ^ a b "Entrez Gene: TRADD TNFRSF1A-associated via death domain". 
  3. ^ Wang, Y; Wu T R, Cai S, Welte T, Chin Y E (July 2000). "Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation". Mol. Cell. Biol. (United States) 20 (13): 4505–12. doi:10.1128/MCB.20.13.4505-4512.2000. ISSN 0270-7306. PMC 85828. PMID 10848577. 
  4. ^ Jiang, Y; Woronicz J D, Liu W, Goeddel D V (January 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science (United States) 283 (5401): 543–6. doi:10.1126/science.283.5401.543. ISSN 0036-8075. PMID 9915703. 
  5. ^ Schütze, S; Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse M L, Heinrich M, Wickel M, Krönke M (April 1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. (United States) 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. ISSN 0021-9258. PMID 10187805. 
  6. ^ Pan, G; O'Rourke K, Chinnaiyan A M, Gentz R, Ebner R, Ni J, Dixit V M (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science (United States) 276 (5309): 111–3. doi:10.1126/science.276.5309.111. ISSN 0036-8075. PMID 9082980. 
  7. ^ a b Hsu, H; Huang J, Shu H B, Baichwal V, Goeddel D V (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity (United States) 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. ISSN 1074-7613. PMID 8612133. 
  8. ^ a b c Hsu, H; Shu H B, Pan M G, Goeddel D V (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell (United States) 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. ISSN 0092-8674. PMID 8565075. 
  9. ^ Shu, H B; Takeuchi M, Goeddel D V (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (United States) 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. ISSN 0027-8424. PMC 19479. PMID 8943045. 
  10. ^ Blankenship, John W; Varfolomeev Eugene, Goncharov Tatiana, Fedorova Anna V, Kirkpatrick Donald S, Izrael-Tomasevic Anita, Phu Lilian, Arnott David, Aghajan Mariam, Zobel Kerry, Bazan J Fernando, Fairbrother Wayne J, Deshayes Kurt, Vucic Domagoj (January 2009). "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)". Biochem. J. (England) 417 (1): 149–60. doi:10.1042/BJ20081885. PMID 18939944. 
  11. ^ Henshall, David C; Araki Tomohiro, Schindler Clara K, Shinoda Sachiko, Lan Jing-Quan, Simon Roger P (September 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". J. Neurochem. (England) 86 (5): 1260–70. doi:10.1046/j.1471-4159.2003.01934.x. ISSN 0022-3042. PMID 12911633. 
  12. ^ Thomas, Lance R; Stillman David J, Thorburn Andrew (September 2002). "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen". J. Biol. Chem. (United States) 277 (37): 34343–8. doi:10.1074/jbc.M204169200. ISSN 0021-9258. PMID 12107169. 
  13. ^ Kitson, J; Raven T, Jiang Y P, Goeddel D V, Giles K M, Pun K T, Grinham C J, Brown R, Farrow S N (November 1996). "A death-domain-containing receptor that mediates apoptosis". Nature (ENGLAND) 384 (6607): 372–5. doi:10.1038/384372a0. ISSN 0028-0836. PMID 8934525. 
  14. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  15. ^ Takeuchi, M; Rothe M, Goeddel D V (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (United States) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708. 
  16. ^ Park, Y C; Ye H, Hsia C, Segal D, Rich R L, Liou H C, Myszka D G, Wu H (June 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell (United States) 101 (7): 777–87. doi:10.1016/S0092-8674(00)80889-2. ISSN 0092-8674. PMID 10892748. 
  17. ^ Tsao, D H; McDonagh T, Telliez J B, Hsu S, Malakian K, Xu G Y, Lin L L (June 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell (United States) 5 (6): 1051–7. doi:10.1016/S1097-2765(00)80270-1. ISSN 1097-2765. PMID 10911999. 
  18. ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. 
  19. ^ Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature (ENGLAND) 385 (6616): 540–4. doi:10.1038/385540a0. ISSN 0028-0836. PMID 9020361. 
  20. ^ Inada, H; Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T, Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD". J. Cell Biol. (United States) 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708. 


Further reading[edit]

External links[edit]