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TNF receptor-associated factor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRAF1 ; EBI6; MGC:10353
External IDs OMIM601711 MGI101836 HomoloGene4138 GeneCards: TRAF1 Gene
RNA expression pattern
PBB GE TRAF1 205599 at tn.png
More reference expression data
Species Human Mouse
Entrez 7185 22029
Ensembl ENSG00000056558 ENSMUSG00000026875
UniProt Q13077 P39428
RefSeq (mRNA) NM_001190945 NM_009421
RefSeq (protein) NP_001177874 NP_033447
Location (UCSC) Chr 9:
123.66 – 123.69 Mb
Chr 2:
34.94 – 34.96 Mb
PubMed search [1] [2]

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.[1]

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.[2]


TRAF1 has been shown to interact with CD30,[3] CFLAR,[4][5] Baculoviral IAP repeat-containing protein 3,[6][7] BIRC2,[6][7][8] Caspase 8,[9][10] HIVEP3,[11] TNFAIP3,[12][13] TRAF2,[14][15] RANK[16][17] and TRAF interacting protein.[18]


  1. ^ Rothe M, Wong SC, Henzel WJ, Goeddel DV (September 1994). "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor". Cell 78 (4): 681–92. doi:10.1016/0092-8674(94)90532-0. PMID 8069916. 
  2. ^ "Entrez Gene: TRAF1 TNF receptor-associated factor 1". 
  3. ^ Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (November 1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. ISSN 0027-8424. PMC 19493. PMID 8943059.  (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  4. ^ Shu, H B; Halpin D R; Goeddel D V (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity (UNITED STATES) 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. ISSN 1074-7613. PMID 9208847. 
  5. ^ Kataoka, T; Budd R C, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (June 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways". Curr. Biol. (ENGLAND) 10 (11): 640–8. doi:10.1016/S0960-9822(00)00512-1. ISSN 0960-9822. PMID 10837247. 
  6. ^ a b Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571. 
  7. ^ a b Li, Xiaoming; Yang Yili; Ashwell Jonathan D (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature (England) 416 (6878): 345–7. doi:10.1038/416345a. ISSN 0028-0836. PMID 11907583. 
  8. ^ Shu, H B; Takeuchi M; Goeddel D V (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. ISSN 0027-8424. PMC 19479. PMID 8943045. 
  9. ^ Micheau, Olivier; Tschopp Jürg (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell (United States) 114 (2): 181–90. doi:10.1016/S0092-8674(03)00521-X. ISSN 0092-8674. PMID 12887920. 
  10. ^ Leo, E; Deveraux Q L; Buchholtz C; Welsh K; Matsuzawa S; Stennicke H R; Salvesen G S; Reed J C (March 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". J. Biol. Chem. (United States) 276 (11): 8087–93. doi:10.1074/jbc.M009450200. ISSN 0021-9258. PMID 11098060. 
  11. ^ Oukka, Mohamed; Kim Sean T; Lugo Geancarlo; Sun Jenny; Wu Lai-Chu; Glimcher Laurie H (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell (United States) 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. ISSN 1097-2765. PMID 11804591. 
  12. ^ Song, H Y; Rothe M; Goeddel D V (June 1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. ISSN 0027-8424. PMC 39093. PMID 8692885. 
  13. ^ Heyninck, K; Beyaert R (January 1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Lett. (NETHERLANDS) 442 (2-3): 147–50. doi:10.1016/S0014-5793(98)01645-7. ISSN 0014-5793. PMID 9928991. 
  14. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  15. ^ Takeuchi, M; Rothe M; Goeddel D V (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (UNITED STATES) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708. 
  16. ^ Galibert, L; Tometsko M E; Anderson D M; Cosman D; Dougall W C (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070. 
  17. ^ Kim, H H; Lee D E; Shin J N; Lee Y S; Jeon Y M; Chung C H; Ni J; Kwon B S; Lee Z H (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951. 
  18. ^ Lee, S Y; Lee S Y; Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". J. Exp. Med. (UNITED STATES) 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. ISSN 0022-1007. PMC 2196258. PMID 9104814. 

Further reading[edit]