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TRAF3 interacting protein 2
Symbols TRAF3IP2 ; ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13
External IDs OMIM607043 MGI2143599 HomoloGene15885 GeneCards: TRAF3IP2 Gene
RNA expression pattern
PBB GE TRAF3IP2 215411 s at tn.png
PBB GE TRAF3IP2 202987 at tn.png
More reference expression data
Species Human Mouse
Entrez 10758 103213
Ensembl ENSG00000056972 ENSMUSG00000019842
UniProt O43734 Q6IR26
RefSeq (mRNA) NM_001164281 NM_134000
RefSeq (protein) NP_001157753 NP_598761
Location (UCSC) Chr 6:
111.88 – 111.93 Mb
Chr 10:
39.61 – 39.66 Mb
PubMed search [1] [2]

Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.[1][2][3]

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.[3]


TRAF3IP2 has been shown to interact with IKBKG.[1][2]


  1. ^ a b Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U (Oct 2000). "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase". Proc Natl Acad Sci U S A 97 (19): 10494–9. doi:10.1073/pnas.190245697. PMC 27052. PMID 10962033. 
  2. ^ a b Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR (Oct 2000). "Act1, an NF-kappa B-activating protein". Proc Natl Acad Sci U S A 97 (19): 10489–93. doi:10.1073/pnas.160265197. PMC 27051. PMID 10962024. 
  3. ^ a b "Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2". 

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