TRAF5

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TNF receptor-associated factor 5
Identifiers
Symbols TRAF5 ; MGC:39780; RNF84
External IDs OMIM602356 HomoloGene27079 GeneCards: TRAF5 Gene
RNA expression pattern
PBB GE TRAF5 204352 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7188 22033
Ensembl ENSG00000082512 ENSMUSG00000026637
UniProt O00463 P70191
RefSeq (mRNA) NM_001033910 NM_011633
RefSeq (protein) NP_001029082 NP_035763
Location (UCSC) Chr 1:
211.5 – 211.55 Mb
Chr 1:
193.82 – 193.92 Mb
PubMed search [1] [2]

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.[1]

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.[2]

Interactions[edit]

TRAF5 has been shown to interact with ASK1,[3][4] TNFRSF13B,[5] CD134,[6] CD30,[7] CD40,[8][9] RANK[10][11][12] and TNFRSF14.[13][14]

References[edit]

  1. ^ Tang XX, Pleasure DE, Ikegaki N (May 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477. 
  2. ^ "Entrez Gene: TRAF5 TNF receptor-associated factor 5". 
  3. ^ Nishitoh, H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977. 
  4. ^ Hoeflich, K P; Yeh W C; Yao Z; Mak T W; Woodgett J R (October 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene (ENGLAND) 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862. 
  5. ^ Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (July 2000). "Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. doi:10.1084/jem.192.1.137. ISSN 0022-1007. PMC 1887716. PMID 10880535. 
  6. ^ Kawamata, S; Hori T; Imura A; Takaori-Kondo A; Uchiyama T (March 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". J. Biol. Chem. (UNITED STATES) 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. ISSN 0021-9258. PMID 9488716. 
  7. ^ Aizawa, S; Nakano H; Ishida T; Horie R; Nagai M; Ito K; Yagita H; Okumura K; Inoue J; Watanabe T (January 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898. 
  8. ^ Tsukamoto, N; Kobayashi N; Azuma S; Yamamoto T; Inoue J (February 1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007. 
  9. ^ Ishida, T K; Tojo T; Aoki T; Kobayashi N; Ohishi T; Watanabe T; Yamamoto T; Inoue J (September 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. ISSN 0027-8424. PMC 38446. PMID 8790348. 
  10. ^ Darnay, B G; Haridas V; Ni J; Moore P A; Aggarwal B B (August 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412. 
  11. ^ Darnay, B G; Ni J; Moore P A; Aggarwal B B (March 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662. 
  12. ^ Galibert, L; Tometsko M E; Anderson D M; Cosman D; Dougall W C (December 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070. 
  13. ^ Hsu, H; Solovyev I; Colombero A; Elliott R; Kelley M; Boyle W J (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN 0021-9258. PMID 9153189. 
  14. ^ Marsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022. 

Further reading[edit]