The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
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^Kim, H H; Lee D E; Shin J N; Lee Y S; Jeon Y M; Chung C H; Ni J; Kwon B S; Lee Z H (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN0014-5793. PMID10025951.
^Wu, Yifan; Liu Junhong; Zhang Zhengping; Huang Huang; Shen Jiayin; Zhang Shuangquan; Jiang Yong; Luo Lan; Yin Zhimin (January 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. (England) 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID18950704.
^Deng, L; Wang C; Spencer E; Yang L; Braun A; You J; Slaughter C; Pickart C; Chen Z J (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell (United States) 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. ISSN0092-8674. PMID11057907.
^Wald, David; Qin Jinzhong; Zhao Zhendong; Qian Youcun; Naramura Mayumi; Tian Liping; Towne Jennifer; Sims John E; Stark George R; Li Xiaoxia (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. (United States) 4 (9): 920–7. doi:10.1038/ni968. ISSN1529-2908. PMID12925853.
^Sorrentino, Alessandro; Thakur Noopur; Grimsby Susanne; Marcusson Anders; von Bulow Verena; Schuster Norbert; Zhang Shouting; Heldin Carl-Henrik; Landström Maréne (October 2008). "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner". Nat. Cell Biol. (England) 10 (10): 1199–207. doi:10.1038/ncb1780. PMID18758450.
^Newton, Kim; Matsumoto Marissa L, Wertz Ingrid E, Kirkpatrick Donald S, Lill Jennie R, Tan Jenille, Dugger Debra, Gordon Nathaniel, Sidhu Sachdev S, Fellouse Frederic A, Komuves Laszlo, French Dorothy M, Ferrando Ronald E, Lam Cynthia, Compaan Deanne, Yu Christine, Bosanac Ivan, Hymowitz Sarah G, Kelley Robert F, Dixit Vishva M (August 2008). "Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies". Cell (United States) 134 (4): 668–78. doi:10.1016/j.cell.2008.07.039. PMID18724939.Cite uses deprecated parameters (help)
Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system". Immunol. Rev.208: 30–49. doi:10.1111/j.0105-2896.2005.00327.x. PMID16313339.