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TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Protein TRAF6 PDB 1lb4.png
PDB rendering based on 1lb4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRAF6 ; MGC:3310; RNF85
External IDs OMIM602355 MGI108072 HomoloGene3395 GeneCards: TRAF6 Gene
RNA expression pattern
PBB GE TRAF6 205558 at tn.png
More reference expression data
Species Human Mouse
Entrez 7189 22034
Ensembl ENSG00000175104 ENSMUSG00000027164
UniProt Q9Y4K3 P70196
RefSeq (mRNA) NM_004620 NM_009424
RefSeq (protein) NP_004611 NP_033450
Location (UCSC) Chr 11:
36.51 – 36.53 Mb
Chr 2:
101.68 – 101.7 Mb
PubMed search [1] [2]

TRAF6 is a TRAF human protein.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.[1]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations


TRAF6 has been shown to interact with SDCBP,[2] IRAK2,[3][4] IRAK1,[2][3][4][5][6][7][8][9][10] MAP3K7IP2,[10][11][12][13][14][15] MAP3K7IP1,[12][13][16] TNFRSF13B,[17] FHL2,[18] CD40,[19][20] IKBKG,[15][21] RANK,[22][23][24][25][26] HSPB2,[27] UBE2N,[28] SIGIRR,[29] TAX1BP1,[9] ASK1,[30][31][32] PPP4C,[33] TNFAIP3,[34][35] Sequestosome 1,[36] MAP3K7[10][11][12][13][16][32][37] and Ubiquitin C.[14][21][33][38][39]


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Further reading[edit]

  • Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837. 
  • Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847. 
  • Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system". Immunol. Rev. 208: 30–49. doi:10.1111/j.0105-2896.2005.00327.x. PMID 16313339. 

External links[edit]