TRAP1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TNF receptor-associated protein 1
Identifiers
Symbols TRAP1 ; HSP 75; HSP75; HSP90L; TRAP-1
External IDs OMIM606219 MGI1915265 HomoloGene9457 ChEMBL: 1075132 GeneCards: TRAP1 Gene
RNA expression pattern
PBB GE TRAP1 201391 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10131 68015
Ensembl ENSG00000126602 ENSMUSG00000005981
UniProt Q12931 Q9CQN1
RefSeq (mRNA) NM_001272049 NM_026508
RefSeq (protein) NP_001258978 NP_080784
Location (UCSC) Chr 16:
3.7 – 3.77 Mb
Chr 16:
4.04 – 4.08 Mb
PubMed search [1] [2]

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.[1][2][3]


Interactions[edit]

TRAP1 has been shown to interact with EXT2,[4] EXT1[4] and Retinoblastoma protein.[5]

References[edit]

  1. ^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318. 
  2. ^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093. 
  3. ^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1". 
  4. ^ a b Simmons, A D; Musy M M, Lopes C S, Hwang L Y, Yang Y P, Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. (ENGLAND) 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594. 
  5. ^ Chen, C F; Chen Y, Dai K, Chen P L, Riley D J, Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. (UNITED STATES) 16 (9): 4691–9. ISSN 0270-7306. PMC 231469. PMID 8756626. 

Further reading[edit]

External links[edit]