TRAT1

T cell receptor associated transmembrane adaptor 1
Identifiers
Symbols	TRAT1; TCRIM; TRIM
External IDs	OMIM: 604962 MGI: 1924897 HomoloGene: 41130 GeneCards: TRAT1 Gene
Gene Ontology Molecular function • transmembrane receptor protein tyrosine kinase adaptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • plasma membrane • plasma membrane • plasma membrane • integral to plasma membrane • T cell receptor complex Biological process • negative regulation of receptor recycling • cellular defense response • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway • positive regulation of T cell receptor signaling pathway • negative regulation of transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50852	77647
Ensembl	ENSG00000163519	ENSMUSG00000030775
UniProt	Q6PIZ9	Q3UU67
RefSeq (mRNA)	NM_016388.2	NM_198297.3
RefSeq (protein)	NP_057472.2	NP_938039.2
Location (UCSC)	Chr 3: 108.54 – 108.57 Mb	Chr 16: 48.73 – 48.77 Mb
PubMed search	[1]	[2]

T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.

Further reading

• Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling.". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796. 
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934. 
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193385. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.