From Wikipedia, the free encyclopedia
Jump to: navigation, search
Three prime repair exonuclease 2
Protein TREX2 PDB 1y97.png
PDB rendering based on 1y97.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol TREX2
External IDs OMIM300370 MGI1346343 HomoloGene8046 GeneCards: TREX2 Gene
EC number
Species Human Mouse
Entrez 11219 24102
Ensembl ENSG00000183479 ENSMUSG00000031372
UniProt Q9BQ50 Q9R1A9
RefSeq (mRNA) NM_080699 NM_011907
RefSeq (protein) NP_542432 NP_036037
Location (UCSC) Chr HG1497_PATCH:
152.61 – 152.64 Mb
Chr X:
73.43 – 73.44 Mb
PubMed search [1] [2]

Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene.[1][2]

This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.[2]


  1. ^ Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem 274 (28): 19655–60. doi:10.1074/jbc.274.28.19655. PMID 10391904. 
  2. ^ a b "Entrez Gene: TREX2 three prime repair exonuclease 2". 

Further reading[edit]