TRIB1

Tribbles homolog 1 (Drosophila)
Identifiers
Symbols	TRIB1; C8FW; GIG2; SKIP1; TRB1
External IDs	OMIM: 609461 MGI: 2443397 HomoloGene: 75216 GeneCards: TRIB1 Gene
Gene Ontology Molecular function • protein kinase activity • protein kinase inhibitor activity • protein binding • ATP binding • transcription factor binding • transferase activity, transferring phosphorus-containing groups • mitogen-activated protein kinase kinase binding • ubiquitin protein ligase binding • ubiquitin-protein ligase regulator activity Cellular component • nucleus • cytoplasm Biological process • protein phosphorylation • negative regulation of protein kinase activity • JNK cascade • negative regulation of smooth muscle cell migration • negative regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • response to lipopolysaccharide • response to lipopolysaccharide • regulation of MAP kinase activity • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of smooth muscle cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10221	211770
Ensembl	ENSG00000173334	ENSMUSG00000032501
UniProt	Q96RU8	Q8K4K4
RefSeq (mRNA)	NM_025195	NM_144549.4
RefSeq (protein)	NP_079471	NP_653132.1
Location (UCSC)	Chr 8: 126.44 – 126.45 Mb	Chr 15: 59.48 – 59.49 Mb
PubMed search	[1]	[2]

Tribbles homolog 1 is a protein that in humans is encoded by the TRIB1 gene.

Further reading

• Tang K, Finley RL, Nie D, Honn KV; Finley (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wu M, Xu LG, Zhai Z, Shu HB (2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J. Biol. Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Kiss-Toth E, Bagstaff SM, Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades". J. Biol. Chem. 279 (41): 42703–8. doi:10.1074/jbc.M407732200. PMID 15299019. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Xu C, Zhang J, Huang X, et al. (2006). "Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP". J. Biol. Chem. 281 (23): 15900–8. doi:10.1074/jbc.M511155200. PMID 16595688. 
• Sung HY, Guan H, Czibula A, et al. (2007). "Human Tribbles-1 Controls Proliferation and Chemotaxis of Smooth Muscle Cells via MAPK Signalling Pathways". J. Biol. Chem. 282 (25): 18379–87. doi:10.1074/jbc.M610792200. PMC 2366084. PMID 17452330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2366084.