TRIB3

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Tribbles pseudokinase 3
Identifiers
Symbols TRIB3 ; C20orf97; NIPK; SINK; SKIP3; TRB3
External IDs OMIM607898 MGI1345675 HomoloGene10902 GeneCards: TRIB3 Gene
RNA expression pattern
PBB GE TRIB3 218145 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57761 228775
Ensembl ENSG00000101255 ENSMUSG00000032715
UniProt Q96RU7 Q8K4K2
RefSeq (mRNA) NM_001301188 NM_144554
RefSeq (protein) NP_001288117 NP_780302
Location (UCSC) Chr 20:
0.36 – 0.38 Mb
Chr 2:
152.34 – 152.34 Mb
PubMed search [1] [2]

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.[3]

Interactions[edit]

TRIB3 has been shown to interact with:


References[edit]

  1. ^ a b Du K, Herzig S, Kulkarni RN, Montminy M (Jun 2003). "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver". Science 300 (5625): 1574–7. doi:10.1126/science.1079817. PMID 12791994. 
  2. ^ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMID 16715410. 
  3. ^ a b "Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)". 
  4. ^ a b c d Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110. 
  5. ^ Bowers AJ, Scully S, Boylan JF (May 2003). "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia". Oncogene 22 (18): 2823–35. doi:10.1038/sj.onc.1206367. PMID 12743605. 
  6. ^ Wu M, Xu LG, Zhai Z, Shu HB (July 2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J. Biol. Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262. 

Further reading[edit]