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Tripartite motif containing 23
Symbols TRIM23 ; ARD1; ARFD1; RNF46
External IDs OMIM601747 MGI1933161 HomoloGene1251 GeneCards: TRIM23 Gene
RNA expression pattern
PBB GE TRIM23 204732 s at tn.png
PBB GE TRIM23 210994 x at tn.png
PBB GE TRIM23 210995 s at tn.png
More reference expression data
Species Human Mouse
Entrez 373 81003
Ensembl ENSG00000113595 ENSMUSG00000021712
UniProt P36406 Q8BGX0
RefSeq (mRNA) NM_001656 NM_030731
RefSeq (protein) NP_001647 NP_109656
Location (UCSC) Chr 5:
64.89 – 64.92 Mb
Chr 13:
104.18 – 104.2 Mb
PubMed search [1] [2]

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.[1][2]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.[2]


TRIM23 has been shown to interact with TRIM31,[3] TRIM29[3] and PSCD1.[4]


  1. ^ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (May 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". J Biol Chem 268 (12): 8801–7. PMID 8473324. 
  2. ^ a b "Entrez Gene: TRIM23 tripartite motif-containing 23". 
  3. ^ a b Reymond, A; Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci P G, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. (England) 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. ISSN 0261-4189. PMC 125245. PMID 11331580. 
  4. ^ Vitale, N; Pacheco-Rodriguez G; Ferrans V J; Riemenschneider W; Moss J; Vaughan M (July 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. (UNITED STATES) 275 (28): 21331–9. doi:10.1074/jbc.M909642199. ISSN 0021-9258. PMID 10748148. 

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