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Tripartite motif containing 28
PDB 1fp0 EBI.jpg
Rendering of 1FP0
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRIM28 ; KAP1; PPP1R157; RNF96; TF1B; TIF1B
External IDs OMIM601742 MGI109274 HomoloGene21175 GeneCards: TRIM28 Gene
RNA expression pattern
PBB GE TRIM28 200990 at tn.png
More reference expression data
Species Human Mouse
Entrez 10155 21849
Ensembl ENSG00000130726 ENSMUSG00000005566
UniProt Q13263 Q62318
RefSeq (mRNA) NM_005762 NM_011588
RefSeq (protein) NP_005753 NP_035718
Location (UCSC) Chr 19:
59.06 – 59.06 Mb
Chr 7:
13.02 – 13.03 Mb
PubMed search [1] [2]

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene.[1][2]


The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.[3]


TRIM28 has been shown to interact with CBX5,[4][5][6][7] ZNF10,[8][9] CEBPB,[10][11] SETDB1[12] and Glucocorticoid receptor.[11]

See also[edit]


  1. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580. 
  2. ^ Capili AD, Schultz DC, RauscherIII FJ, Borden KL (January 2001). "Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains". EMBO J. 20 (1–2): 165–77. doi:10.1093/emboj/20.1.165. PMC 140198. PMID 11226167. 
  3. ^ "Entrez Gene: TRIM28 tripartite motif-containing 28". 
  4. ^ Nielsen, Anders Lade; Sanchez Cecilia; Ichinose Hiroshi; Cerviño Margarita; Lerouge Thierry; Chambon Pierre; Losson Régine (November 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497. 
  5. ^ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (September 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074. 
  6. ^ Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697. 
  7. ^ Lechner, M S; Begg G E; Speicher D W; Rauscher F J (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122. 
  8. ^ Moosmann, P; Georgiev O; Le Douarin B; Bourquin J P; Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. (ENGLAND) 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. ISSN 0305-1048. PMC 146346. PMID 9016654. 
  9. ^ Peng, H; Begg G E; Harper S L; Friedman J R; Speicher D W; Rauscher F J (June 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. (UNITED STATES) 275 (24): 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030. 
  10. ^ Rooney, J W; Calame K L (November 2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. (United States) 15 (22): 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMC 312827. PMID 12269264.  (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  11. ^ a b Chang, C J; Chen Y L; Lee S C (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880–7. ISSN 0270-7306. PMC 109174. PMID 9742105. 
  12. ^ Schultz, David C; Ayyanathan Kasirajan; Negorev Dmitri; Maul Gerd G; Rauscher Frank J (April 2002). "SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins". Genes Dev. (United States) 16 (8): 919–32. doi:10.1101/gad.973302. ISSN 0890-9369. PMC 152359. PMID 11959841. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links[edit]