TRIM28

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Tripartite motif containing 28
PDB 1fp0 EBI.jpg
Rendering of 1FP0
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TRIM28 ; KAP1; RNF96; TF1B; TIF1B
External IDs OMIM601742 MGI109274 HomoloGene21175 GeneCards: TRIM28 Gene
RNA expression pattern
PBB GE TRIM28 200990 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10155 21849
Ensembl ENSG00000130726 ENSMUSG00000005566
UniProt Q13263 Q62318
RefSeq (mRNA) NM_005762 NM_011588
RefSeq (protein) NP_005753 NP_035718
Location (UCSC) Chr 19:
59.06 – 59.06 Mb
Chr 7:
13.02 – 13.03 Mb
PubMed search [1] [2]

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene.[1][2]

Function[edit]

The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.[3]

Interactions[edit]

TRIM28 has been shown to interact with CBX5,[4][5][6][7] ZNF10,[8][9] CEBPB,[10][11] SETDB1[12] and Glucocorticoid receptor.[11]

See also[edit]

References[edit]

  1. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580. 
  2. ^ Capili AD, Schultz DC, RauscherIII FJ, Borden KL (January 2001). "Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains". EMBO J. 20 (1–2): 165–77. doi:10.1093/emboj/20.1.165. PMC 140198. PMID 11226167. 
  3. ^ "Entrez Gene: TRIM28 tripartite motif-containing 28". 
  4. ^ Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (November 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497. 
  5. ^ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (September 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074. 
  6. ^ Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697. 
  7. ^ Lechner, M S; Begg G E, Speicher D W, Rauscher F J (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122. 
  8. ^ Moosmann, P; Georgiev O, Le Douarin B, Bourquin J P, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. (ENGLAND) 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. ISSN 0305-1048. PMC 146346. PMID 9016654. 
  9. ^ Peng, H; Begg G E, Harper S L, Friedman J R, Speicher D W, Rauscher F J (June 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. (UNITED STATES) 275 (24): 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030. 
  10. ^ Rooney, J W; Calame K L (November 2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. (United States) 15 (22): 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMC 312827. PMID 12269264.  (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  11. ^ a b Chang, C J; Chen Y L, Lee S C (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880–7. ISSN 0270-7306. PMC 109174. PMID 9742105. 
  12. ^ Schultz, David C; Ayyanathan Kasirajan, Negorev Dmitri, Maul Gerd G, Rauscher Frank J (April 2002). "SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins". Genes Dev. (United States) 16 (8): 919–32. doi:10.1101/gad.973302. ISSN 0890-9369. PMC 152359. PMID 11959841. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


External links[edit]