TRIM55

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Tripartite motif containing 55
Identifiers
Symbols TRIM55 ; MURF-2; RNF29; muRF2
External IDs OMIM606469 MGI3036269 HomoloGene13205 GeneCards: TRIM55 Gene
Orthologs
Species Human Mouse
Entrez 84675 381485
Ensembl ENSG00000147573 ENSMUSG00000060913
UniProt Q9BYV6 G3X8Y1
RefSeq (mRNA) NM_033058 NM_001081281
RefSeq (protein) NP_149047 NP_001074750
Location (UCSC) Chr 8:
67.04 – 67.09 Mb
Chr 3:
19.64 – 19.69 Mb
PubMed search [1] [2]

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.[1][2]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.[2]

References[edit]

  1. ^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782. 
  2. ^ a b "Entrez Gene: TRIM55 tripartite motif-containing 55". 

Further reading[edit]