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Tripartite motif containing 6
Symbols TRIM6 ; RNF89
External IDs OMIM607564 MGI2137352 HomoloGene14381 GeneCards: TRIM6 Gene
Species Human Mouse
Entrez 117854 94088
Ensembl ENSG00000121236 ENSMUSG00000072244
UniProt Q9C030 Q8BGE7
RefSeq (mRNA) NM_001003818 NM_001013616
RefSeq (protein) NP_001003818 NP_001013637
Location (UCSC) Chr 11:
5.62 – 5.63 Mb
Chr 7:
104.22 – 104.24 Mb
PubMed search [1] [2]

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[1][2]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[2]


  1. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580. 
  2. ^ a b "Entrez Gene: TRIM6 tripartite motif-containing 6". 

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